Page 93 - 中國動物保健雜誌2017年第19卷第11期
P. 93
??研究
doi:10.3969/j.issn.1008-4754.2017.11.042
??多糖稀?液??瘟疫苗免疫效果的影?
万思敬
(山?省青?市?物?生?督所 山?青? 266199)
摘 要: ?研究??多糖稀?液??瘟活疫苗的免疫增?作用,? 60 ??奶仔??机分成 2 ?(?照?和
??多糖?),?照?和??多糖?分?接种?菌生理?水和??多糖稀?液稀?的?瘟疫苗。?果?示,
在疫苗免疫后 7、14、21 和 28d,??多糖?的?瘟抗体效价(log2)??照?分?提高 5.3%(P>0.05)、9.8%
(P<0.05)、14.0%(P<0.05)、14.2%(P<0.05)。表明利用??多糖稀?液稀??瘟疫苗可?著提高?瘟疫苗
免疫后的抗体水平,增??瘟疫苗的免疫效果。
???: ??多糖;?瘟疫苗;免疫效果
Effects of Astragalus Polysaccharide Diluent on the Immune Efficacy of
Swine Fever Vaccine
Wan Sijing
(Qingdao Animal Health Supervision Institute Qingdao Shandong 266199)
Abstract: To study the immune enhancement effects of Astragalus Polysaccharides dilution on swine fever vac-
cine, 60 weaned piglets were randomly divided into 2 groups (control group and astragalus polysaccharide group),
control group and astragalus polysaccharide group were respectively inoculated with sterile saline and astragalus
polysaccharide dilution of swine fever vaccine. Results showed that in 7th, 14th, 21st, 28th day after vaccination,
swine fever antibody titer (log2)of Astragalus polysaccharide group were respectively increased by 5.3%(P>0.05),
9.8%(P<0.05), 14%(P<0.05) and 14.2%(P<0.05), compared with the control group. The results showed that the
swine fever vaccine with astragalus polysaccharide diluent can significantly improve the antibody level after swine
fever vaccine immunization, and enhance the immune efficacy of classical swine fever vaccine.
Keywords: astragalus polysaccharides, classical swine fever vaccine, immune efficacy
?瘟 (Classical swine fever,CSF)是由?瘟病毒 1 材料与方法
(Classical swine fever virus,CSFV) 引起的?的一种 1.1 ??多糖、仔?
高度接触性?染病,是目前威?我????的主要 ??多糖?自山?方舟生物科技有限公司;21
疫病之一,我?采取以疫苗免疫接种?主的防控措 日??奶仔??自?州思保???。
施,因此提高疫苗的免疫效果??瘟的防控至?重 1.2 疫苗、??盒
要 。??多糖是中???的主要活性成分,具有? ?瘟活疫苗(?胞源)?自??永?生物制?有
[1]
?机体?生干扰素、提高淋巴?胞?量和?化率及 限公司;?瘟病毒正向?接血凝 (IHA)抗体???
[2]
增?机体免疫功能等生物?活性 。本研究探?了 ?盒?自中???科?院?州??研究所;
???多糖作?稀?液稀??瘟疫苗后??瘟疫 1.3 ??多糖稀?液的制?
苗免疫效果的影?,???多糖在?瘟疫苗免疫中 ? 1g ??多糖溶解于 1,000mL ?化水中,高?
的推??用提供理?支持。 ?菌后 4℃保存?用。
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